| Pair Name | Thymoquinone, Zoledronic acid | ||
| Phytochemical Name | Thymoquinone (PubChem CID: 10281 ) | ||
| Anticancer drug Name | Zoledronic acid (PubChem CID: 68740 ) | ||
| Structure of Phytochemical |
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MOL
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| Structure of Anticancer Drug |
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| Pair Name | Thymoquinone, Zoledronic acid | |||
| Disease Info | [ICD-11: 2C82] | Prostate cancer | Investigative | |
| Biological Phenomena | Induction-->DNA fragmentation | |||
| Gene Regulation | Up-regulation | Expression | CASP3 | hsa836 |
| Up-regulation | Expression | CASP7 | hsa840 | |
| In Vitro Model | PC-3 | Prostate carcinoma | Homo sapiens (Human) | CVCL_0035 |
| DU145 | Prostate carcinoma | Homo sapiens (Human) | CVCL_0105 | |
| Result | TQ and ZA had minimal hematological and non-hematological toxicity profile compared to cytotoxic agents. So, this combination may be an alternative approach for patients who are unable to be treated by conventional treatments because of poor performance status. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Enhanced cytotoxicity and apoptosis by thymoquinone in combination with zoledronic acid in hormone- and drug-resistant prostate cancer cell lines. J BUON. 2014 Oct-Dec;19(4):1055-61. | Click |
